Yes — unlock the D6 by defeating Mom’s Heart ten times to unlock Blue Baby (???), then clear the Cathedral boss while playing as ???.
Unlocking the D6 is a two-stage gate: ten Mom’s Heart clears followed by a Cathedral boss kill as ???.
Unlocking the D6 is a two-stage gate: ten Mom’s Heart clears followed by a Cathedral boss kill as ???.
In The Binding of Isaac: Rebirth (2026), the D6 is a reroll device that swaps your active item for a fresh random pick from the item pool. To make it appear, you’ll need to grind Mom’s Heart ten times first—that unlocks Blue Baby (???). Then start a new run as ??? and push through to the Cathedral, which is basically Mom’s Heart but harder. Beat that boss, and the D6 permanently joins your item pool for every future run, no matter which character you pick.
Follow the exact five-step sequence to unlock the D6.
Follow the exact five-step sequence to unlock the D6.
- Clear Mom’s Heart ten times to unlock Blue Baby (???).
- Start a fresh run as ???.
- Navigate to and defeat the Cathedral boss (the tougher Mom’s Heart variant).
- Once the Cathedral boss bites the dust, the D6 is added to your permanent item pool.
- From that point on, the D6 can pop up as a random drop or in Devil/Angel rooms in every future run, no matter who you play.
(Pro tip: peek at the character-select screen—??? only shows up after Mom’s Heart has been dusted ten times.)
If the D6 still isn’t unlocked, verify ??? availability, try an alternate boss route, or inspect game files.
If the D6 still isn’t unlocked, verify ??? availability, try an alternate boss route, or inspect game files.
- Double-check the unlock: Open the character selection screen; ??? won’t appear until Mom’s Heart has been dusted ten times.
- Try an alternate route: A few players swear defeating It Lives as ??? can also unlock the D6, but the official path is still Mom’s Heart x10 plus Cathedral cleanup.
- Inspect your files: Open the game’s
resourcesfolder and review the item pool settings. Rarely, a corrupted file or active mod can quietly disable the D6.
Prevent future unlock confusion by tracking Mom’s Heart clears and planning rerolls wisely.
Prevent future unlock confusion by tracking Mom’s Heart clears and planning rerolls wisely.
- Track Mom’s Heart clears in a notebook or on the Rebirth Wiki; the game doesn’t show a counter on screen.
- Start runs with a character that already has the D6 unlocked (e.g., ???) if you want the reroll right away; later characters like Tainted Isaac still get it once unlocked, but you’ll need to unlock them first.
- Use the D6 carefully—its power comes with risk, so swap only when you can afford to gamble your current item.
How do you unlock Blue Baby?
Blue Baby, also known as ???, is a character unlocked by defeating Mom’s Heart ten times . He starts with three Soul Hearts, and his health meter works differently—he can’t gain red heart containers. If an item tries to give him a red heart container (even an empty one), it turns into a Soul Heart instead.
How do you unlock the Dice in The Binding of Isaac?
The Dice is an unlockable activated item. It’s a single six-sided die, red with black spots for each number. At first it’s locked away, but you can unlock it by defeating It Lives as ??? (Mom’s Heart can be defeated via Ankh) .
How do you unlock the D6 in Reddit?
First things first—the D6 is unlocked by beating the Cathedral boss with Blue Baby . My best single tip? Learn to spot those tinted rocks; they’re your early warning system.
How do you unlock all Isaac characters?
- Judas: Defeat boss in The Womb 2 for the first time.
- The Book Of Belial: Defeat boss in The Womb 2 for the first time.
- The Noose: Defeat boss in The Womb 2 the second time.
- The Nail: Defeat boss in The Womb 2 the third time.
- A Quarter: Defeat boss in The Womb 2 the fourth time.
Does Isaac start with the D6?
The D6 is special—Isaac only starts with it once it’s unlocked .
How do I unlock Apollyon?
Apollyon, added in The Binding of Isaac: Afterbirth †, is unlocked by defeating Mega Satan for the first time .
How do you unlock It Lives?
It Lives is the beefed-up version of Mom’s Heart. You unlock her after beating Mom’s Heart 11 times . She can even spawn bosses like Teratoma that Mom’s Heart can’t.
How do I unlock Greedier mode?
Greedier Mode, fresh in Afterbirth ♰, is unlocked by dumping 500 coins in the Greed Machine . The normal floors (Basement through Shop) now throw eleven required waves at you and add a twelfth optional wave that opens the Devil Deal.
How do you unlock the Lost?
Find the missing poster first.
That means beating the Lamb while playing as Isaac . Since the Lamb sits in the Final Boss of the Dark Room, you’ll need to unlock it first. Grab the Negative by beating Satan five times.
How do you get the Tainted Isaac characters?
It’s definitely a grind, but once you get into the rhythm of The Binding of Isaac, you’ll fall into a groove. Take each character through the Ascent to the Home area and use the Red/Cracked Key in the room before Mom’s Room to unlock every Tainted character.
What is a Mulliboom?
The Mulliboom is a Monster in The Binding of Isaac: Rebirth that hangs out on Basement, Cellar, and Burning Basement floors. It chases Isaac and explodes on contact, but only dishes out half a heart of damage.
How do I get to the Isaac boss?
Isaac is the big bad of The Cathedral. You can reach him by killing Mom’s Heart 11 times and then dusting It Lives! , or by entering an Angel Room after Mom’s Heart and touching the beam of light that appears.
How do you unlock the D20 in Isaac?
Fun fact: In the original The Binding of Isaac, the D20 was unlocked by beating Isaac (Boss) as Isaac .
What does the D6 room do in The Binding of Isaac?
Pair Sharp Plug with any health-regeneration setup and the D6 lets you reroll items indefinitely . Even Key Piece 2 can be rerolled to snag a free Angel Room item.
What is a D6 dice?
D6—aka six-sided dice—are perfect for rolling a random number between 1 and 6. Our d6 dice sets include 12 standard 16mm dice. Kraken Dice is your go-to source for d6 dice sets online.
